Assay Detail
Functional
CHEMBL920547
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Reduction of HCV RNA levels by HCV replicon assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.09 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388502 | — | — | 1 | 5.82 |
| CHEMBL223608 | — | — | 1 | 5.41 |
| CHEMBL223720 | — | — | 1 | 5.27 |
| CHEMBL224788 | — | — | 1 | 4.54 |
| CHEMBL224999 | — | — | 1 | 4.43 |
| CHEMBL427101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388502 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL223608 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL223720 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL224788 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL224999 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL427101 | — | EC50 | - | — | - |