Assay Detail
Binding
CHEMBL920646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum recombinant falcipain-2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.49 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434743 | — | — | 1 | 6.20 |
| CHEMBL223654 | — | — | 1 | 6.14 |
| CHEMBL224312 | — | — | 1 | 5.65 |
| CHEMBL225449 | — | — | 1 | 5.58 |
| CHEMBL224025 | — | — | 1 | 5.50 |
| CHEMBL225646 | — | — | 1 | 5.42 |
| CHEMBL224893 | — | — | 1 | 5.23 |
| CHEMBL225323 | — | — | 1 | 4.96 |
| CHEMBL225184 | — | — | 1 | 4.74 |
| CHEMBL224258 | — | — | 1 | - |
| CHEMBL387974 | — | — | 1 | - |
| CHEMBL225644 | — | — | 1 | - |
| CHEMBL225592 | — | — | 1 | - |
| CHEMBL388317 | — | — | 1 | - |
| CHEMBL427253 | — | — | 1 | - |
| CHEMBL388101 | — | — | 1 | - |
| CHEMBL224260 | — | — | 1 | - |
| CHEMBL387860 | — | — | 1 | - |
| CHEMBL224891 | — | — | 1 | - |
| CHEMBL389869 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434743 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL223654 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL224312 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL225449 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL224025 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL225646 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL224893 | — | IC50 | = | 5850.0 | nM | 5.23 |
| CHEMBL225323 | — | IC50 | = | 11070.0 | nM | 4.96 |
| CHEMBL225184 | — | IC50 | = | 18220.0 | nM | 4.74 |
| CHEMBL224258 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL387974 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL225644 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL225592 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL388317 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL427253 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL388101 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL224260 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL387860 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL224891 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL389869 | — | IC50 | > | 20000.0 | nM | - |