Assay Detail
Functional
CHEMBL920647
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Antiparasitic activity against Plasmodium falciparum W2
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.40 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224025 | — | — | 1 | 7.11 |
| CHEMBL389869 | — | — | 1 | 6.96 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.62 |
| CHEMBL224260 | — | — | 1 | 6.60 |
| CHEMBL434743 | — | — | 1 | 6.57 |
| CHEMBL387860 | — | — | 1 | 6.42 |
| CHEMBL225449 | — | — | 1 | 6.36 |
| CHEMBL223654 | — | — | 1 | 5.97 |
| CHEMBL224258 | — | — | 1 | 5.97 |
| CHEMBL224312 | — | — | 1 | 5.43 |
| CHEMBL387974 | — | — | 1 | - |
| CHEMBL225644 | — | — | 1 | - |
| CHEMBL225592 | — | — | 1 | - |
| CHEMBL388317 | — | — | 1 | - |
| CHEMBL225184 | — | — | 1 | - |
| CHEMBL427253 | — | — | 1 | - |
| CHEMBL225646 | — | — | 1 | - |
| CHEMBL224893 | — | — | 1 | - |
| CHEMBL225323 | — | — | 1 | - |
| CHEMBL224891 | — | — | 1 | - |
| CHEMBL388101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224025 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL389869 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL224260 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL434743 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL387860 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL225449 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL223654 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL224258 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL224312 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL387974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388317 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225184 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL427253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225646 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL225323 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL224891 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL388101 | — | IC50 | > | 10000.0 | nM | - |