Assay Detail
Functional
CHEMBL920651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Xenopus recombinant Plx1 expressed in Sf21 cells by GST-Cdc25 substrate phosphorylation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus |
| Cell Type | Sf21 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL4519) ↗| Type | SINGLE PROTEIN |
| Organism | Xenopus laevis |
Publication
Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.49 | 4.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228043 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228043 | — | IC50 | = | 32500.0 | nM | 4.49 |