Assay Detail
Binding
CHEMBL920803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.97 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 10.66 |
| CHEMBL370941 | — | — | 1 | 9.82 |
| CHEMBL372643 | — | — | 1 | 8.28 |
| CHEMBL388746 | — | — | 1 | 8.11 |
| CHEMBL193087 | — | — | 1 | 8.00 |
| CHEMBL370038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | Ki | = | 0.022 | nM | 10.66 |
| CHEMBL370941 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL372643 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL388746 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL193087 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL370038 | — | Ki | = | 0.0052 | nM | - |