Assay Detail
Binding
CHEMBL920804
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Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.47 | 10.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 10.77 |
| CHEMBL370941 | — | — | 1 | 10.10 |
| CHEMBL388746 | — | — | 1 | 9.12 |
| CHEMBL372643 | — | — | 1 | 8.80 |
| CHEMBL193087 | — | — | 1 | 8.54 |
| CHEMBL370038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | Ki | = | 0.017 | nM | 10.77 |
| CHEMBL370941 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL388746 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL372643 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL193087 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL370038 | — | Ki | = | 0.0039 | nM | - |