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Assay Detail

CHEMBL921331

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytostatic activity in mouse L1210 cells assessed as inhibition of cell growth after 72 hrs
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.
Silhár P, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R.
Bioorg Med Chem (2008) 16 : 2329 -2366
PubMed 18078757 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 25 - -
IC50 9 5.50 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL917 FLOXURIDINE 4.0 1 7.92
CHEMBL408517 1 5.80
CHEMBL441730 1 5.32
CHEMBL258941 1 5.29
CHEMBL262348 1 5.11
CHEMBL260795 1 4.92
CHEMBL408502 1 4.84
CHEMBL259718 1 4.77
CHEMBL261616 1 -
CHEMBL259357 1 -
CHEMBL260140 1 -
CHEMBL260347 1 -
CHEMBL409904 1 -
CHEMBL259670 1 -
CHEMBL410221 1 -
CHEMBL410082 1 -
CHEMBL429513 1 -
CHEMBL259509 1 -
CHEMBL409871 1 -
CHEMBL259852 1 -
CHEMBL258859 1 -
CHEMBL262613 1 -
CHEMBL261135 1 -
CHEMBL260796 1 -
CHEMBL261409 1 -
CHEMBL406702 1 -
CHEMBL411667 1 -
CHEMBL262349 1 -
CHEMBL265944 1 -
CHEMBL406118 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL917 FLOXURIDINE IC50 = 12.0 nM 7.92
CHEMBL408517 IC50 = 1590.0 nM 5.80
CHEMBL441730 IC50 = 4800.0 nM 5.32
CHEMBL258941 IC50 = 5100.0 nM 5.29
CHEMBL262348 IC50 = 7800.0 nM 5.11
CHEMBL260795 IC50 = 12160.0 nM 4.92
CHEMBL408502 IC50 = 14300.0 nM 4.84
CHEMBL259718 IC50 = 17000.0 nM 4.77
CHEMBL260347 Activity - -
CHEMBL408952 Activity - -
CHEMBL409904 Activity - -
CHEMBL259670 Activity - -
CHEMBL410221 Activity - -
CHEMBL410082 Activity - -
CHEMBL429513 Activity - -
CHEMBL259509 Activity - -
CHEMBL409871 Activity - -
CHEMBL259357 Activity - -
CHEMBL411602 Activity - -
CHEMBL259719 Activity - -
CHEMBL411689 Activity - -
CHEMBL260140 Activity - -
CHEMBL261616 Activity - -
CHEMBL259852 Activity - -
CHEMBL258859 Activity - -
CHEMBL262613 Activity - -
CHEMBL261135 Activity - -
CHEMBL260796 Activity - -
CHEMBL261409 Activity - -
CHEMBL406702 Activity - -
CHEMBL411667 Activity - -
CHEMBL262349 Activity - -
CHEMBL265944 Activity - -
CHEMBL406118 IC50 > 30000.0 nM -