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Assay Detail

CHEMBL921335

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus 1b after 3 days
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.
Silhár P, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R.
Bioorg Med Chem (2008) 16 : 2329 -2366
PubMed 18078757 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 34 4.71 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73809 1 6.64
CHEMBL259718 1 5.52
CHEMBL408517 1 5.22
CHEMBL262348 1 5.16
CHEMBL441730 1 5.05
CHEMBL406118 1 5.00
CHEMBL259357 1 4.89
CHEMBL411602 1 4.85
CHEMBL408502 1 4.82
CHEMBL259852 1 4.70
CHEMBL261616 1 4.70
CHEMBL261409 1 4.68
CHEMBL260140 1 4.41
CHEMBL258941 1 4.39
CHEMBL260795 1 4.38
CHEMBL409904 1 4.36
CHEMBL259670 1 4.34
CHEMBL408952 1 4.21
CHEMBL261135 1 4.19
CHEMBL406702 1 4.06
CHEMBL265944 1 4.06
CHEMBL259719 1 4.04
CHEMBL262613 1 -
CHEMBL259509 1 -
CHEMBL429513 1 -
CHEMBL262349 1 -
CHEMBL411667 1 -
CHEMBL260796 1 -
CHEMBL411689 1 -
CHEMBL409871 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73809 EC50 = 230.0 nM 6.64
CHEMBL259718 EC50 = 3000.0 nM 5.52
CHEMBL408517 EC50 = 6000.0 nM 5.22
CHEMBL262348 EC50 = 7000.0 nM 5.16
CHEMBL441730 EC50 = 9000.0 nM 5.05
CHEMBL406118 EC50 = 10000.0 nM 5.00
CHEMBL259357 EC50 = 13000.0 nM 4.89
CHEMBL411602 EC50 = 14000.0 nM 4.85
CHEMBL408502 EC50 = 15000.0 nM 4.82
CHEMBL259852 EC50 = 20000.0 nM 4.70
CHEMBL261616 EC50 = 20000.0 nM 4.70
CHEMBL261409 EC50 = 21000.0 nM 4.68
CHEMBL260140 EC50 = 39000.0 nM 4.41
CHEMBL258941 EC50 = 41000.0 nM 4.39
CHEMBL260795 EC50 = 42000.0 nM 4.38
CHEMBL409904 EC50 = 44000.0 nM 4.36
CHEMBL259670 EC50 = 46000.0 nM 4.34
CHEMBL408952 EC50 = 62000.0 nM 4.21
CHEMBL261135 EC50 = 65000.0 nM 4.19
CHEMBL406702 EC50 = 87000.0 nM 4.06
CHEMBL265944 EC50 = 87000.0 nM 4.06
CHEMBL259719 EC50 = 91000.0 nM 4.04
CHEMBL262613 EC50 = 186000.0 nM -
CHEMBL259509 EC50 > 250000.0 nM -
CHEMBL429513 EC50 > 100000.0 nM -
CHEMBL262349 EC50 > 100000.0 nM -
CHEMBL411667 EC50 > 100000.0 nM -
CHEMBL260796 EC50 > 100000.0 nM -
CHEMBL411689 EC50 > 100000.0 nM -
CHEMBL409871 EC50 > 100000.0 nM -
CHEMBL258859 EC50 > 100000.0 nM -
CHEMBL410082 EC50 > 100000.0 nM -
CHEMBL410221 EC50 > 100000.0 nM -
CHEMBL260347 EC50 > 100000.0 nM -