Assay Detail
Binding
CHEMBL921413
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Displacement of [131I]IMTO from CYP450c 11 in Wistar rat adrenal membrane
37
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.05 | 9.15 |
| logIC50 | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 9.15 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | — | 1 | 9.05 |
| CHEMBL933 | METYRAPOL | — | 1 | 8.99 |
| CHEMBL681 | ETOMIDATE | 4.0 | 2 | 8.97 |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 8.94 |
| CHEMBL407094 | — | — | 1 | 8.85 |
| CHEMBL263127 | — | — | 1 | 8.54 |
| CHEMBL261379 | — | — | 2 | 8.54 |
| CHEMBL405684 | — | — | 1 | 8.49 |
| CHEMBL261038 | — | — | 1 | 8.48 |
| CHEMBL259660 | — | — | 1 | 8.45 |
| CHEMBL406437 | — | — | 2 | 8.43 |
| CHEMBL261039 | — | — | 1 | 8.36 |
| CHEMBL261771 | — | — | 1 | 8.35 |
| CHEMBL260871 | — | — | 1 | 8.21 |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | 1.0 | 2 | 8.05 |
| CHEMBL406747 | — | — | 1 | 8.05 |
| CHEMBL264703 | — | — | 2 | 7.85 |
| CHEMBL441731 | — | — | 2 | 7.68 |
| CHEMBL406326 | — | — | 2 | 7.54 |
| CHEMBL260469 | — | — | 2 | 7.22 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 7.08 |
| CHEMBL282567 | PROADIFEN | 2.0 | 1 | 6.86 |
| CHEMBL408591 | — | — | 2 | 6.67 |
| CHEMBL406436 | — | — | 2 | 6.31 |
| CHEMBL261507 | — | — | 1 | 6.06 |
| CHEMBL408404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL1498 | DESOXYCORTICOSTERONE | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL933 | METYRAPOL | IC50 | = | 1.02 | nM | 8.99 |
| CHEMBL681 | ETOMIDATE | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL934 | METYRAPONE | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL407094 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL263127 | — | IC50 | = | 2.89 | nM | 8.54 |
| CHEMBL261379 | — | IC50 | = | 2.89 | nM | 8.54 |
| CHEMBL405684 | — | IC50 | = | 3.26 | nM | 8.49 |
| CHEMBL261038 | — | IC50 | = | 3.29 | nM | 8.48 |
| CHEMBL259660 | — | IC50 | = | 3.58 | nM | 8.45 |
| CHEMBL406437 | — | IC50 | = | 3.69 | nM | 8.43 |
| CHEMBL261039 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL261771 | — | IC50 | = | 4.44 | nM | 8.35 |
| CHEMBL260871 | — | IC50 | = | 6.23 | nM | 8.21 |
| CHEMBL406747 | — | IC50 | = | 8.95 | nM | 8.05 |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | IC50 | = | 8.98 | nM | 8.05 |
| CHEMBL264703 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL441731 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL406326 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL260469 | — | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 82.9 | nM | 7.08 |
| CHEMBL282567 | PROADIFEN | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL408591 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL406436 | — | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL261507 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL260469 | — | logIC50 | = | 1.78 | — | - |
| CHEMBL264703 | — | logIC50 | = | 1.18 | — | - |
| CHEMBL261379 | — | logIC50 | = | 0.46 | — | - |
| CHEMBL260402 | IODOMETOMIDATE I-123, R- | logIC50 | = | 0.954 | — | - |
| CHEMBL441731 | — | logIC50 | = | 1.32 | — | - |
| CHEMBL406326 | — | logIC50 | = | 1.46 | — | - |
| CHEMBL408591 | — | logIC50 | = | 2.33 | — | - |
| CHEMBL406436 | — | logIC50 | = | 2.69 | — | - |
| CHEMBL406437 | — | logIC50 | = | 0.57 | — | - |
| CHEMBL681 | ETOMIDATE | logIC50 | = | 0.033 | — | - |
| CHEMBL408404 | — | IC50 | = | 122670.0 | nM | - |