Assay Detail
Binding
CHEMBL921442
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Inhibition of human HDAC1 expressed in 293T cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.26 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.44 |
| CHEMBL257972 | AZUMAMIDE C | — | 1 | 5.93 |
| CHEMBL402363 | AZUMAMIDE E | — | 1 | 5.91 |
| CHEMBL402727 | AZUMAMIDE B | — | 1 | 5.74 |
| CHEMBL255714 | AZUMAMIDE A | — | 1 | - |
| CHEMBL257973 | AZUMAMIDE D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL257972 | AZUMAMIDE C | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL402363 | AZUMAMIDE E | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL402727 | AZUMAMIDE B | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL255714 | AZUMAMIDE A | IC50 | > | 50000.0 | nM | - |
| CHEMBL257973 | AZUMAMIDE D | IC50 | > | 50000.0 | nM | - |