Assay Detail
Functional
CHEMBL921471
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Antiproliferative activity against human 1A9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.33 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 9.52 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.44 |
| CHEMBL536094 | — | — | 1 | 6.52 |
| CHEMBL536093 | — | — | 1 | 5.50 |
| CHEMBL554150 | — | — | 1 | 5.40 |
| CHEMBL536768 | — | — | 1 | 4.62 |
| CHEMBL535642 | — | — | 1 | 4.30 |
| CHEMBL536315 | — | — | 1 | - |
| CHEMBL541395 | — | — | 1 | - |
| CHEMBL558772 | — | — | 1 | - |
| CHEMBL535866 | — | — | 1 | - |
| CHEMBL541650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL536094 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL536093 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL554150 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL536768 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL535642 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL536315 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL541395 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL558772 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL535866 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL541650 | — | IC50 | > | 50000.0 | nM | - |