Assay Detail
Binding
CHEMBL921472
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Inhibition of rat brain tubulin polymerization
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.97 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | 2.0 | 1 | 9.15 |
| CHEMBL554150 | — | — | 1 | 6.22 |
| CHEMBL256922 | TUBULYSIN-A | — | 1 | 6.12 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.96 |
| CHEMBL536094 | — | — | 1 | 5.82 |
| CHEMBL536768 | — | — | 1 | 5.64 |
| CHEMBL536093 | — | — | 1 | 5.57 |
| CHEMBL535866 | — | — | 1 | 5.36 |
| CHEMBL535642 | — | — | 1 | 4.96 |
| CHEMBL536315 | — | — | 1 | 4.89 |
| CHEMBL541395 | — | — | 1 | - |
| CHEMBL558772 | — | — | 1 | - |
| CHEMBL541650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182319 | TALTOBULIN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL554150 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL256922 | TUBULYSIN-A | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL536094 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL536768 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL536093 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL535866 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL535642 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL536315 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL541395 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL558772 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL541650 | — | IC50 | > | 20000.0 | nM | - |