Assay Detail
Binding
CHEMBL921483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 8.40 |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | 8.05 |
| CHEMBL260185 | — | — | 1 | 7.22 |
| CHEMBL259011 | — | — | 1 | 7.10 |
| CHEMBL261541 | — | — | 1 | 6.72 |
| CHEMBL261714 | — | — | 1 | 6.57 |
| CHEMBL409643 | — | — | 1 | 6.52 |
| CHEMBL259012 | — | — | 1 | 6.07 |
| CHEMBL260398 | — | — | 1 | 5.91 |
| CHEMBL260619 | — | — | 1 | 5.71 |
| CHEMBL406929 | — | — | 1 | 5.34 |
| CHEMBL405652 | — | — | 1 | 5.32 |
| CHEMBL263887 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL254316 | RALTEGRAVIR | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL260185 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL259011 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL261541 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL261714 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL409643 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL259012 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL260398 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL260619 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL406929 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL405652 | — | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL263887 | — | IC50 | = | 86080.0 | nM | 4.07 |