Assay Detail
Binding
CHEMBL921616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKK2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.15 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129857 | AS-602868 | 1.0 | 1 | 7.21 |
| CHEMBL257805 | — | — | 1 | 7.19 |
| CHEMBL254556 | — | — | 1 | 6.89 |
| CHEMBL402041 | — | — | 1 | 6.64 |
| CHEMBL257402 | — | — | 1 | 6.60 |
| CHEMBL254793 | — | — | 1 | 6.57 |
| CHEMBL257189 | — | — | 1 | 6.42 |
| CHEMBL403615 | — | — | 1 | 6.40 |
| CHEMBL256524 | — | — | 1 | 6.39 |
| CHEMBL402628 | — | — | 1 | 6.39 |
| CHEMBL256148 | — | — | 1 | 6.36 |
| CHEMBL256523 | — | — | 1 | 6.27 |
| CHEMBL401919 | — | — | 1 | 6.22 |
| CHEMBL428424 | — | — | 1 | 6.16 |
| CHEMBL256347 | — | — | 1 | 6.00 |
| CHEMBL256940 | — | — | 1 | 5.82 |
| CHEMBL255436 | — | — | 1 | 5.60 |
| CHEMBL402314 | — | — | 1 | 5.44 |
| CHEMBL256285 | — | — | 1 | 5.40 |
| CHEMBL440404 | — | — | 1 | 5.18 |
| CHEMBL257769 | — | — | 1 | 5.05 |
| CHEMBL404688 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129857 | AS-602868 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL257805 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL254556 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL402041 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL257402 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL254793 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL257189 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL403615 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL256524 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL402628 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL256148 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL256523 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL401919 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL428424 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL256347 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL256940 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL255436 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL402314 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL256285 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL440404 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL257769 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL404688 | — | IC50 | = | 8900.0 | nM | 5.05 |