Assay Detail
Functional
CHEMBL921620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-stimulated E-selectin promoter transfected human A549 cells after 6 hrs
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.65 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257402 | — | — | 1 | 6.54 |
| CHEMBL402628 | — | — | 1 | 5.90 |
| CHEMBL256523 | — | — | 1 | 5.82 |
| CHEMBL257189 | — | — | 1 | 5.74 |
| CHEMBL256524 | — | — | 1 | 5.72 |
| CHEMBL401919 | — | — | 1 | 5.68 |
| CHEMBL403615 | — | — | 1 | 5.42 |
| CHEMBL257805 | — | — | 1 | 5.24 |
| CHEMBL402041 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257402 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL402628 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL256523 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL257189 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL256524 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL401919 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL403615 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL257805 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL402041 | — | IC50 | = | 17800.0 | nM | 4.75 |