Assay Detail
Functional
CHEMBL921658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nicotinic acid receptor agonists differentially activate downstream effectors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.41 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393428 | — | — | 1 | 5.89 |
| CHEMBL255877 | — | — | 1 | 5.77 |
| CHEMBL429495 | — | — | 1 | 5.66 |
| CHEMBL238002 | — | — | 1 | 5.58 |
| CHEMBL394441 | — | — | 1 | 5.38 |
| CHEMBL573 | NIACIN | 4.0 | 1 | 4.17 |
| CHEMBL391574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393428 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL255877 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL429495 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL238002 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL394441 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL573 | NIACIN | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL391574 | — | IC50 | = | 434000.0 | nM | - |