Assay Detail
Functional
CHEMBL921660
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Inhibition of isoproterenol-induced lipolysis in human subcutaneous adipocytes after 5 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Adipocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nicotinic acid receptor agonists differentially activate downstream effectors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.16 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573 | NIACIN | 4.0 | 1 | 6.05 |
| CHEMBL391574 | — | — | 1 | 5.85 |
| CHEMBL393428 | — | — | 1 | 5.28 |
| CHEMBL429495 | — | — | 1 | 4.49 |
| CHEMBL394441 | — | — | 1 | 4.14 |
| CHEMBL255877 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573 | NIACIN | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL391574 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL393428 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL429495 | — | EC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL394441 | — | EC50 | = | 72500.0 | nM | 4.14 |
| CHEMBL255877 | — | EC50 | = | 102700.0 | nM | - |