Assay Detail
Binding
CHEMBL921744
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Inhibition of lyase activity of DNA polymerase beta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of DNA polymerase beta: activity and mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.42 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.58 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.47 |
| CHEMBL259025 | EDGEWORIN | — | 1 | 4.41 |
| CHEMBL400247 | STIGMASTEROL | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 26250.0 | nM | 4.58 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL259025 | EDGEWORIN | IC50 | = | 38880.0 | nM | 4.41 |
| CHEMBL400247 | STIGMASTEROL | IC50 | = | 60280.0 | nM | 4.22 |