Assay Detail
Binding
CHEMBL921802
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Inhibition of mouse COX2 V349I mutant pre-incubated before addition of [1-14C]arachidonic acid
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| Ki | 2 | 6.04 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404108 | LUMIRACOXIB | 4.0 | 2 | 6.12 |
| CHEMBL259218 | — | — | 1 | 5.96 |
| CHEMBL76084 | — | — | 1 | - |
| CHEMBL260111 | — | — | 1 | - |
| CHEMBL407368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404108 | LUMIRACOXIB | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL259218 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL404108 | LUMIRACOXIB | Inhibition | < | 20.0 | % | - |
| CHEMBL76084 | — | Inhibition | < | 20.0 | % | - |
| CHEMBL260111 | — | Inhibition | < | 20.0 | % | - |
| CHEMBL407368 | — | Inhibition | < | 20.0 | % | - |