Assay Detail
Binding
CHEMBL921928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of yeast G6PD
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glucose-6-phosphate 1-dehydrogenase (CHEMBL1075249) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.92 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 6.75 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 6.64 |
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 6.62 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.60 |
| CHEMBL408233 | — | — | 1 | 4.66 |
| CHEMBL408232 | — | — | 1 | 4.25 |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | - |
| CHEMBL264167 | (-)-GALLOCATECHIN | — | 1 | - |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL408233 | — | IC50 | = | 21760.0 | nM | 4.66 |
| CHEMBL408232 | — | IC50 | = | 56370.0 | nM | 4.25 |
| CHEMBL200715 | (-)-CATECHIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL264167 | (-)-GALLOCATECHIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | > | 1000000.0 | nM | - |