Assay Detail
Binding
CHEMBL921935
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Inhibition of human JNK1 by radiometric assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.92 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258618 | — | — | 1 | 8.19 |
| CHEMBL259484 | — | — | 1 | 8.17 |
| CHEMBL437107 | — | — | 1 | 8.14 |
| CHEMBL260064 | — | — | 1 | 8.12 |
| CHEMBL260065 | — | — | 1 | 8.09 |
| CHEMBL258705 | — | — | 1 | 8.07 |
| CHEMBL259720 | — | — | 1 | 8.03 |
| CHEMBL259554 | — | — | 1 | 8.02 |
| CHEMBL261413 | — | — | 1 | 8.00 |
| CHEMBL409350 | — | — | 1 | 8.00 |
| CHEMBL411083 | — | — | 1 | 8.00 |
| CHEMBL258631 | — | — | 1 | 7.96 |
| CHEMBL258845 | — | — | 1 | 7.96 |
| CHEMBL259555 | — | — | 1 | 7.55 |
| CHEMBL259060 | — | — | 1 | 7.52 |
| CHEMBL427561 | — | — | 1 | 7.48 |
| CHEMBL406408 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258618 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL259484 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL437107 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL260064 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL260065 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL258705 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL259720 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL259554 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL261413 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL409350 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL411083 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL258631 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL258845 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL259555 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL259060 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL427561 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL406408 | — | IC50 | = | 43.0 | nM | 7.37 |