Assay Detail
Functional
CHEMBL921965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.71 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407909 | — | — | 1 | 9.00 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.62 |
| CHEMBL76781 | — | — | 1 | 7.28 |
| CHEMBL272942 | MECOPROP | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407909 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL39 | SEROTONIN | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL76781 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL272942 | MECOPROP | EC50 | = | 120.0 | nM | 6.92 |