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Assay Detail

CHEMBL922055

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human cSrc-vSrc fusion protein expressed in rat fibroblast cells by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Fibroblast
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: identification of potent 7-amino analogs.
Boschelli DH, Wu B, Ye F, Durutlic H, Golas JM, Lucas J, Boschelli F.
Bioorg Med Chem (2008) 16 : 405 -412
PubMed 17905586 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.39 7.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428976 1 7.07
CHEMBL288441 BOSUTINIB 4.0 1 7.00
CHEMBL409683 1 6.75
CHEMBL124333 1 6.72
CHEMBL261531 1 6.52
CHEMBL429712 1 6.44
CHEMBL261532 1 6.41
CHEMBL261591 1 6.15
CHEMBL407971 1 5.82
CHEMBL406936 1 5.80
CHEMBL260938 1 5.57
CHEMBL264140 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428976 IC50 = 85.0 nM 7.07
CHEMBL288441 BOSUTINIB IC50 = 100.0 nM 7.00
CHEMBL409683 IC50 = 180.0 nM 6.75
CHEMBL124333 IC50 = 190.0 nM 6.72
CHEMBL261531 IC50 = 300.0 nM 6.52
CHEMBL429712 IC50 = 360.0 nM 6.44
CHEMBL261532 IC50 = 390.0 nM 6.41
CHEMBL261591 IC50 = 710.0 nM 6.15
CHEMBL407971 IC50 = 1500.0 nM 5.82
CHEMBL406936 IC50 = 1600.0 nM 5.80
CHEMBL260938 IC50 = 2700.0 nM 5.57
CHEMBL264140 IC50 > 10000.0 nM -