Assay Detail
Functional
CHEMBL922241
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Cytotoxicity against mouse L1210 cells after 4 hrs by microculture tetrazolium assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.12 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244140 | — | — | 1 | 5.96 |
| CHEMBL264661 | — | — | 1 | 5.66 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 5.55 |
| CHEMBL243930 | — | — | 1 | 5.17 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 5.00 |
| CHEMBL259432 | — | — | 1 | 4.67 |
| CHEMBL388648 | BIS-IMIDE A | — | 1 | 4.49 |
| CHEMBL265691 | — | — | 1 | 4.48 |
| CHEMBL406938 | — | — | 1 | - |
| CHEMBL265446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244140 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL264661 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL243930 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL259432 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL388648 | BIS-IMIDE A | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL265691 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL406938 | — | IC50 | - | — | - | |
| CHEMBL265446 | — | IC50 | > | 50000.0 | nM | - |