Assay Detail
Functional
CHEMBL922243
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Cytotoxicity against human HT29 cells after 4 hrs by microculture tetrazolium assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.07 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265446 | — | — | 1 | 6.24 |
| CHEMBL264661 | — | — | 1 | 5.60 |
| CHEMBL244140 | — | — | 1 | 5.25 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 5.24 |
| CHEMBL388648 | BIS-IMIDE A | — | 1 | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 4.86 |
| CHEMBL243930 | — | — | 1 | 4.76 |
| CHEMBL265691 | — | — | 1 | 4.42 |
| CHEMBL259432 | — | — | 1 | 4.24 |
| CHEMBL406938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265446 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL264661 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL244140 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL388648 | BIS-IMIDE A | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL243930 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL265691 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL259432 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL406938 | — | IC50 | - | — | - |