Assay Detail
Functional
CHEMBL922245
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Cytotoxicity against human A549 cells after 3 days by SRB assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.46 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259989 | — | — | 1 | 8.70 |
| CHEMBL259778 | — | — | 1 | 8.40 |
| CHEMBL406853 | — | — | 1 | 8.22 |
| CHEMBL261342 | — | — | 1 | 8.05 |
| CHEMBL260223 | — | — | 1 | 7.75 |
| CHEMBL261876 | — | — | 1 | 7.75 |
| CHEMBL261294 | — | — | 1 | 7.72 |
| CHEMBL261330 | — | — | 1 | 7.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL258925 | — | — | 1 | 7.58 |
| CHEMBL260224 | — | — | 1 | 7.50 |
| CHEMBL259225 | — | — | 1 | 7.27 |
| CHEMBL260541 | — | — | 1 | 7.09 |
| CHEMBL261341 | — | — | 1 | 6.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.94 |
| CHEMBL259990 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259989 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL259778 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL406853 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL261342 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL260223 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL261876 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL261294 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL261330 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL258925 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL260224 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL259225 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL260541 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL261341 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL259990 | — | IC50 | = | 9020.0 | nM | 5.04 |