Assay Detail
Binding
CHEMBL922293
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Displacement of [3H]SB-2587891 from Escherichia coli ribosomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Subcellular | Ribosome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.26 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1658 | RETAPAMULIN | 4.0 | 1 | 8.70 |
| CHEMBL261309 | — | — | 1 | 8.12 |
| CHEMBL412133 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1658 | RETAPAMULIN | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL261309 | — | Kd | = | 7.5 | nM | 8.12 |
| CHEMBL412133 | — | Kd | = | 11.1 | nM | 7.96 |