Assay Detail
Binding
CHEMBL922321
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ditolylguanidine from sigma 2 opioid receptor in rat liver
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.65 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.70 |
| CHEMBL406018 | — | — | 1 | 7.44 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL259732 | — | — | 1 | 5.98 |
| CHEMBL138809 | — | — | 1 | 5.89 |
| CHEMBL410832 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL406018 | — | Ki | = | 36.2 | nM | 7.44 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.1 | nM | 7.11 |
| CHEMBL259732 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL138809 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL410832 | — | Ki | = | 1750.0 | nM | 5.76 |