Assay Detail
Binding
CHEMBL922472
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Displacement of [3H]TBOB from GABAA receptor in Sprague-Dawley rat cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and GABA(A) receptor activity of oxygen-bridged neurosteroid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.27 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 6.48 |
| CHEMBL259201 | — | — | 1 | 6.38 |
| CHEMBL259828 | — | — | 1 | 6.29 |
| CHEMBL260226 | — | — | 1 | 6.13 |
| CHEMBL210952 | ELTANOLONE | 2.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL259201 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL259828 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL260226 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL210952 | ELTANOLONE | IC50 | = | 830.0 | nM | 6.08 |