Assay Detail
Binding
CHEMBL922679
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Inhibition of Escherichia coli DXR
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.74 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.27 |
| CHEMBL205338 | FR-900098 | — | 1 | 7.21 |
| CHEMBL261794 | — | — | 1 | 7.14 |
| CHEMBL260214 | — | — | 1 | 7.06 |
| CHEMBL258981 | — | — | 1 | 7.01 |
| CHEMBL404612 | — | — | 1 | 5.96 |
| CHEMBL408882 | — | — | 1 | 5.52 |
| CHEMBL407837 | BIS(PIVALOYLOXYMETHYL)ESTER | — | 1 | - |
| CHEMBL261371 | — | — | 1 | - |
| CHEMBL443766 | — | — | 1 | - |
| CHEMBL258516 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL205338 | FR-900098 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL261794 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL260214 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL258981 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL404612 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL408882 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL407837 | BIS(PIVALOYLOXYMETHYL)ESTER | IC50 | > | 30000.0 | nM | - |
| CHEMBL261371 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL443766 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL258516 | — | IC50 | > | 3000.0 | nM | - |