Assay Detail
Functional
CHEMBL922680
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Antimalarial activity against Plasmodium falciparum 3D7 in infected human erythrocytes after 48 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.37 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407837 | BIS(PIVALOYLOXYMETHYL)ESTER | — | 1 | 7.29 |
| CHEMBL261371 | — | — | 1 | 7.00 |
| CHEMBL261794 | — | — | 1 | 6.62 |
| CHEMBL260214 | — | — | 1 | 6.44 |
| CHEMBL205338 | FR-900098 | — | 1 | 6.37 |
| CHEMBL258981 | — | — | 1 | 6.01 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 5.92 |
| CHEMBL404612 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407837 | BIS(PIVALOYLOXYMETHYL)ESTER | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL261371 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL261794 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL260214 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL205338 | FR-900098 | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL258981 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL404612 | — | IC50 | = | 4900.0 | nM | 5.31 |