Assay Detail
Binding
CHEMBL922698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]diprenorphine from recombinant kappa opioid receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.00 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358043 | HETEROCODEINE | — | 1 | 7.64 |
| CHEMBL410907 | — | — | 1 | 7.34 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.18 |
| CHEMBL261048 | — | — | 1 | 6.23 |
| CHEMBL408422 | — | — | 1 | 5.51 |
| CHEMBL258669 | — | — | 1 | 5.31 |
| CHEMBL412301 | — | — | 1 | 5.26 |
| CHEMBL409743 | — | — | 1 | 4.94 |
| CHEMBL485 | CODEINE | 4.0 | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358043 | HETEROCODEINE | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL410907 | — | Ki | = | 45.5 | nM | 7.34 |
| CHEMBL70 | MORPHINE | Ki | = | 65.5 | nM | 7.18 |
| CHEMBL261048 | — | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL408422 | — | Ki | = | 3090.0 | nM | 5.51 |
| CHEMBL258669 | — | Ki | = | 4910.0 | nM | 5.31 |
| CHEMBL412301 | — | Ki | = | 5430.0 | nM | 5.26 |
| CHEMBL409743 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL485 | CODEINE | Ki | = | 25411.0 | nM | 4.59 |