Assay Detail
Binding
CHEMBL922769
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Displacement of [3H]U-69593 from cloned kappa opioid receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5'-halogenated analogs of oxymorphindole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.53 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427706 | — | — | 1 | 6.80 |
| CHEMBL401094 | — | — | 1 | 6.60 |
| CHEMBL248839 | — | — | 1 | 6.51 |
| CHEMBL248840 | — | — | 1 | 6.44 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427706 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL401094 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL248839 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL248840 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 515.0 | nM | 6.29 |