Assay Detail
Functional
CHEMBL922901
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Inhibition of cholesterol synthesis in rat hepatocyte
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 9.31 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437774 | — | — | 1 | 10.00 |
| CHEMBL249906 | — | — | 1 | 10.00 |
| CHEMBL401293 | — | — | 1 | 10.00 |
| CHEMBL398240 | — | — | 1 | 10.00 |
| CHEMBL250317 | — | — | 1 | 10.00 |
| CHEMBL399315 | — | — | 1 | 10.00 |
| CHEMBL399773 | — | — | 1 | 9.70 |
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 9.57 |
| CHEMBL250953 | — | — | 1 | 9.52 |
| CHEMBL250088 | — | — | 1 | 9.52 |
| CHEMBL399313 | — | — | 1 | 9.52 |
| CHEMBL399360 | — | — | 1 | 9.40 |
| CHEMBL249724 | — | — | 1 | 9.40 |
| CHEMBL400973 | — | — | 1 | 9.30 |
| CHEMBL249273 | — | — | 1 | 9.30 |
| CHEMBL400560 | — | — | 1 | 9.30 |
| CHEMBL438694 | — | — | 1 | 9.22 |
| CHEMBL403127 | — | — | 1 | 9.15 |
| CHEMBL400874 | — | — | 1 | 9.15 |
| CHEMBL249884 | — | — | 1 | 9.15 |
| CHEMBL398551 | — | — | 1 | 9.05 |
| CHEMBL250090 | — | — | 1 | 9.05 |
| CHEMBL394937 | — | — | 1 | 9.00 |
| CHEMBL399771 | — | — | 1 | 8.92 |
| CHEMBL400747 | — | — | 1 | 8.92 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 8.89 |
| CHEMBL250749 | — | — | 1 | 8.82 |
| CHEMBL398239 | — | — | 1 | 8.82 |
| CHEMBL250500 | — | — | 1 | 8.80 |
| CHEMBL250707 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437774 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL249906 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL401293 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL398240 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL250317 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL399315 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL399773 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1496 | ROSUVASTATIN | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL250953 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL250088 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL399313 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL399360 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL249724 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL400973 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL400560 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL249273 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL438694 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL403127 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL400874 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL249884 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL398551 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL250090 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL394937 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL399771 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL400747 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL250749 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL398239 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL250500 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL250707 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL251499 | — | IC50 | = | 4.9 | nM | 8.31 |