Assay Detail
Functional
CHEMBL922937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against RSV long A with F1 protein K394R mutation in HEp2 cells
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Respiratory syncytial virus |
| Cell Type | HEp2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Respiratory syncytial virus (CHEMBL612679) ↗| Type | ORGANISM |
| Organism | Respiratory syncytial virus |
Publication
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 57 | 6.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247852 | — | — | 1 | 8.70 |
| CHEMBL418539 | — | — | 1 | 8.40 |
| CHEMBL399053 | — | — | 1 | 8.40 |
| CHEMBL246832 | — | — | 1 | 8.30 |
| CHEMBL246830 | — | — | 1 | 8.05 |
| CHEMBL247003 | — | — | 1 | 7.80 |
| CHEMBL247846 | — | — | 1 | 7.75 |
| CHEMBL246831 | — | — | 1 | 7.51 |
| CHEMBL398945 | — | — | 1 | 7.36 |
| CHEMBL246841 | — | — | 1 | 7.33 |
| CHEMBL247004 | — | — | 1 | 7.30 |
| CHEMBL247853 | — | — | 1 | 7.24 |
| CHEMBL399233 | — | — | 1 | 7.24 |
| CHEMBL246612 | — | — | 1 | 7.02 |
| CHEMBL400489 | — | — | 1 | 6.96 |
| CHEMBL248018 | — | — | 1 | 6.93 |
| CHEMBL247001 | — | — | 1 | 6.90 |
| CHEMBL439402 | — | — | 1 | 6.87 |
| CHEMBL246828 | — | — | 1 | 6.78 |
| CHEMBL399436 | — | — | 1 | 6.75 |
| CHEMBL246826 | — | — | 1 | 6.71 |
| CHEMBL246820 | — | — | 1 | 6.64 |
| CHEMBL247854 | — | — | 1 | 6.44 |
| CHEMBL247847 | — | — | 1 | 6.32 |
| CHEMBL399437 | — | — | 1 | 6.20 |
| CHEMBL248022 | — | — | 1 | 6.20 |
| CHEMBL248024 | — | — | 1 | 6.16 |
| CHEMBL247850 | — | — | 1 | 6.16 |
| CHEMBL404853 | — | — | 1 | 6.15 |
| CHEMBL248023 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247852 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL418539 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL399053 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL246832 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL246830 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL247003 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL247846 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL246831 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL398945 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL246841 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL247004 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL247853 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL399233 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL246612 | — | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL400489 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL248018 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL247001 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL439402 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL246828 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL399436 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL246826 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL246820 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL247854 | — | EC50 | = | 363.0 | nM | 6.44 |
| CHEMBL247847 | — | EC50 | = | 476.0 | nM | 6.32 |
| CHEMBL248022 | — | EC50 | = | 631.0 | nM | 6.20 |
| CHEMBL399437 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL248024 | — | EC50 | = | 694.0 | nM | 6.16 |
| CHEMBL247850 | — | EC50 | = | 692.0 | nM | 6.16 |
| CHEMBL404853 | — | EC50 | = | 715.0 | nM | 6.15 |
| CHEMBL248023 | — | EC50 | = | 725.0 | nM | 6.14 |
| CHEMBL400847 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL248017 | — | EC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL247221 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL399051 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL246615 | — | EC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL247843 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL247851 | — | EC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL246829 | — | EC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL99951 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL401052 | — | EC50 | = | 234000.0 | nM | - |
| CHEMBL243876 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL246822 | — | EC50 | = | 213000.0 | nM | - |
| CHEMBL399129 | — | EC50 | = | 123000.0 | nM | - |
| CHEMBL247845 | — | EC50 | = | 241000.0 | nM | - |
| CHEMBL247844 | — | EC50 | = | 230000.0 | nM | - |
| CHEMBL246614 | — | EC50 | = | 182000.0 | nM | - |
| CHEMBL246613 | — | EC50 | = | 187000.0 | nM | - |
| CHEMBL245992 | — | EC50 | = | 238000.0 | nM | - |
| CHEMBL248234 | — | EC50 | = | 192000.0 | nM | - |
| CHEMBL248235 | — | EC50 | = | 230000.0 | nM | - |