Assay Detail
Binding
CHEMBL923041
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Inhibition of HCV NS3 protease by FRET assay
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 5.98 | 9.18 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 9.18 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 7.85 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.41 |
| CHEMBL258843 | — | — | 1 | 6.51 |
| CHEMBL259152 | — | — | 1 | 6.46 |
| CHEMBL408047 | — | — | 1 | 6.21 |
| CHEMBL258984 | — | — | 1 | 6.11 |
| CHEMBL259478 | — | — | 1 | 6.08 |
| CHEMBL436688 | — | — | 1 | 6.04 |
| CHEMBL264323 | — | — | 1 | 5.96 |
| CHEMBL259363 | — | — | 1 | 5.92 |
| CHEMBL540191 | — | — | 1 | 5.85 |
| CHEMBL246632 | — | — | 1 | 5.75 |
| CHEMBL259193 | — | — | 1 | 5.70 |
| CHEMBL402469 | — | — | 1 | 5.50 |
| CHEMBL261778 | — | — | 1 | 5.41 |
| CHEMBL436893 | — | — | 1 | 5.30 |
| CHEMBL260783 | — | — | 1 | 5.23 |
| CHEMBL407203 | — | — | 1 | 5.17 |
| CHEMBL407079 | — | — | 1 | 4.92 |
| CHEMBL261787 | — | — | 1 | 4.77 |
| CHEMBL405518 | CORBOXYLIC ACID | — | 1 | 4.18 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL218394 | BOCEPREVIR | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL258843 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL259152 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL408047 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL258984 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL259478 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL436688 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL264323 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL259363 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL540191 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL246632 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL259193 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL402469 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL261778 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL436893 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL260783 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL407203 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL407079 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL261787 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL405518 | CORBOXYLIC ACID | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL258734 | DANOPREVIR | IC50 | < | 0.25 | nM | - |