Assay Detail
Functional
CHEMBL923045
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum MP14
26
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and exploration of novel curcumin analogues as anti-malarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 13 | - | - |
| IC50 | 13 | 5.46 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | — | 2 | 6.35 |
| CHEMBL428441 | — | — | 2 | 6.12 |
| CHEMBL258632 | — | — | 2 | 6.05 |
| CHEMBL258739 | — | — | 2 | 5.68 |
| CHEMBL261297 | — | — | 2 | 5.60 |
| CHEMBL440408 | — | — | 2 | 5.38 |
| CHEMBL140 | CURCUMIN | 3.0 | 2 | 5.38 |
| CHEMBL409639 | — | — | 2 | 5.32 |
| CHEMBL260079 | — | — | 2 | 5.27 |
| CHEMBL181529 | — | — | 2 | 5.10 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | — | 2 | 5.08 |
| CHEMBL258741 | — | — | 2 | 5.04 |
| CHEMBL410334 | — | — | 2 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL180239 | CURCUMIN PYRAZOLE | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL428441 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL258632 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL258739 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL261297 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL140 | CURCUMIN | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL440408 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL409639 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL260079 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL181529 | — | IC50 | = | 7920.0 | nM | 5.10 |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL258741 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL410334 | — | IC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL440408 | — | MIC | = | 17200.0 | nM | - |
| CHEMBL140 | CURCUMIN | MIC | = | 14400.0 | nM | - |
| CHEMBL410334 | — | MIC | = | 41200.0 | nM | - |
| CHEMBL181529 | — | MIC | = | 25300.0 | nM | - |
| CHEMBL261297 | — | MIC | = | 15300.0 | nM | - |
| CHEMBL180239 | CURCUMIN PYRAZOLE | MIC | = | 3600.0 | nM | - |
| CHEMBL258741 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL428441 | — | MIC | = | 4800.0 | nM | - |
| CHEMBL258739 | — | MIC | = | 12900.0 | nM | - |
| CHEMBL260079 | — | MIC | = | 23100.0 | nM | - |
| CHEMBL258632 | — | MIC | = | 5100.0 | nM | - |
| CHEMBL261295 | TETRAMETHOXYCURCUMIN | MIC | = | 29100.0 | nM | - |
| CHEMBL409639 | — | MIC | = | 21400.0 | nM | - |