Assay Detail
Binding
CHEMBL923066
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Inhibition of Plasmodium falciparum Pfmrk
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.16 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344314 | — | — | 1 | 6.16 |
| CHEMBL148333 | — | — | 1 | 4.16 |
| CHEMBL41631 | — | — | 1 | - |
| CHEMBL104264 | — | — | 1 | - |
| CHEMBL1233654 | — | — | 1 | - |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | - |
| CHEMBL143054 | — | — | 1 | - |
| CHEMBL75773 | — | — | 1 | - |
| CHEMBL429298 | — | — | 1 | - |
| CHEMBL249089 | — | — | 1 | - |
| CHEMBL250517 | — | — | 1 | - |
| CHEMBL251113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344314 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL148333 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL41631 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL104264 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1233654 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL38380 | FASUDIL | IC50 | > | 500000.0 | nM | - |
| CHEMBL143054 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL75773 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL429298 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL249089 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL250517 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL251113 | — | IC50 | > | 500000.0 | nM | - |