Assay Detail
Functional
CHEMBL923068
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Antimalarial activity against drug-resistant Plasmodium falciparum W2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.16 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104264 | — | — | 1 | 5.68 |
| CHEMBL75773 | — | — | 1 | 5.37 |
| CHEMBL1233654 | — | — | 1 | 5.27 |
| CHEMBL41631 | — | — | 1 | 4.82 |
| CHEMBL251113 | — | — | 1 | 4.64 |
| CHEMBL344314 | — | — | 1 | - |
| CHEMBL148333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104264 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL75773 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1233654 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL41631 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL251113 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL344314 | — | IC50 | > | 72000.0 | nM | - |
| CHEMBL148333 | — | IC50 | > | 37000.0 | nM | - |