Assay Detail
Binding
CHEMBL923077
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Inhibition of human cathepsin B
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.65 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248889 | — | — | 1 | 6.77 |
| CHEMBL400387 | — | — | 1 | 6.55 |
| CHEMBL249712 | — | — | 1 | 6.54 |
| CHEMBL399063 | — | — | 1 | 6.47 |
| CHEMBL249698 | — | — | 1 | 6.38 |
| CHEMBL251327 | — | — | 1 | 6.00 |
| CHEMBL249915 | — | — | 1 | 5.96 |
| CHEMBL400750 | — | — | 1 | 5.88 |
| CHEMBL398553 | — | — | 1 | 5.73 |
| CHEMBL249507 | — | — | 1 | 5.70 |
| CHEMBL400728 | — | — | 1 | 5.56 |
| CHEMBL250919 | — | — | 1 | 5.53 |
| CHEMBL250720 | — | — | 1 | 5.46 |
| CHEMBL400972 | — | — | 1 | 5.44 |
| CHEMBL250121 | — | — | 1 | 5.41 |
| CHEMBL251101 | — | — | 1 | 5.39 |
| CHEMBL222649 | — | — | 1 | 5.35 |
| CHEMBL251117 | — | — | 1 | 5.32 |
| CHEMBL437501 | — | — | 1 | 5.28 |
| CHEMBL251719 | — | — | 1 | 5.18 |
| CHEMBL251114 | — | — | 1 | 5.14 |
| CHEMBL249495 | — | — | 1 | 5.11 |
| CHEMBL436636 | — | — | 1 | 5.09 |
| CHEMBL443319 | — | — | 1 | 5.07 |
| CHEMBL250119 | — | — | 1 | 5.01 |
| CHEMBL427883 | — | — | 1 | - |
| CHEMBL437579 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248889 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL400387 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL249712 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL399063 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL249698 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL251327 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL249915 | — | IC50 | = | 1104.0 | nM | 5.96 |
| CHEMBL400750 | — | IC50 | = | 1319.0 | nM | 5.88 |
| CHEMBL398553 | — | IC50 | = | 1844.0 | nM | 5.73 |
| CHEMBL249507 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL400728 | — | IC50 | = | 2777.0 | nM | 5.56 |
| CHEMBL250919 | — | IC50 | = | 2971.0 | nM | 5.53 |
| CHEMBL250720 | — | IC50 | = | 3453.0 | nM | 5.46 |
| CHEMBL400972 | — | IC50 | = | 3612.0 | nM | 5.44 |
| CHEMBL250121 | — | IC50 | = | 3854.0 | nM | 5.41 |
| CHEMBL251101 | — | IC50 | = | 4041.0 | nM | 5.39 |
| CHEMBL222649 | — | IC50 | = | 4504.0 | nM | 5.35 |
| CHEMBL251117 | — | IC50 | = | 4813.0 | nM | 5.32 |
| CHEMBL437501 | — | IC50 | = | 5239.0 | nM | 5.28 |
| CHEMBL251719 | — | IC50 | = | 6629.0 | nM | 5.18 |
| CHEMBL251114 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL249495 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL436636 | — | IC50 | = | 8029.0 | nM | 5.09 |
| CHEMBL443319 | — | IC50 | = | 8507.0 | nM | 5.07 |
| CHEMBL250119 | — | IC50 | = | 9724.0 | nM | 5.01 |
| CHEMBL427883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL437579 | — | IC50 | > | 10000.0 | nM | - |