Assay Detail
Binding
CHEMBL923080
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Inhibition of mouse recombinant cathepsin K
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.01 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437501 | — | — | 1 | 7.37 |
| CHEMBL222649 | — | — | 1 | 6.41 |
| CHEMBL400387 | — | — | 1 | 5.99 |
| CHEMBL250720 | — | — | 1 | 5.88 |
| CHEMBL443319 | — | — | 1 | 5.83 |
| CHEMBL249915 | — | — | 1 | 5.78 |
| CHEMBL251719 | — | — | 1 | 5.59 |
| CHEMBL250119 | — | — | 1 | 5.23 |
| CHEMBL400750 | — | — | 1 | - |
| CHEMBL251327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437501 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL222649 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL400387 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL250720 | — | IC50 | = | 1324.0 | nM | 5.88 |
| CHEMBL443319 | — | IC50 | = | 1464.0 | nM | 5.83 |
| CHEMBL249915 | — | IC50 | = | 1646.0 | nM | 5.78 |
| CHEMBL251719 | — | IC50 | = | 2553.0 | nM | 5.59 |
| CHEMBL250119 | — | IC50 | = | 5835.0 | nM | 5.23 |
| CHEMBL400750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL251327 | — | IC50 | > | 10000.0 | nM | - |