Assay Detail
Binding
CHEMBL923082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat spleen cathepsin S
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.99 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222649 | — | — | 1 | 8.77 |
| CHEMBL443319 | — | — | 1 | 7.82 |
| CHEMBL400750 | — | — | 1 | 7.68 |
| CHEMBL251719 | — | — | 1 | 7.36 |
| CHEMBL250720 | — | — | 1 | 7.18 |
| CHEMBL249915 | — | — | 1 | 6.37 |
| CHEMBL251327 | — | — | 1 | 6.12 |
| CHEMBL400387 | — | — | 1 | 5.98 |
| CHEMBL437501 | — | — | 1 | 5.61 |
| CHEMBL250119 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222649 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL443319 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL400750 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL251719 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL250720 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL249915 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL251327 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL400387 | — | IC50 | = | 1051.0 | nM | 5.98 |
| CHEMBL437501 | — | IC50 | = | 2441.0 | nM | 5.61 |
| CHEMBL250119 | — | IC50 | > | 10000.0 | nM | - |