Assay Detail
Binding
CHEMBL923141
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Inhibition of Txk
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.08 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249317 | — | — | 1 | 9.40 |
| CHEMBL249097 | — | — | 1 | 8.70 |
| CHEMBL398422 | — | — | 1 | 7.55 |
| CHEMBL248676 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249317 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL249097 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL398422 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL248676 | — | IC50 | = | 220.0 | nM | 6.66 |