Assay Detail
Functional
CHEMBL923203
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Antiproliferative activity against human HT29 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.33 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248116 | — | — | 1 | 5.70 |
| CHEMBL391387 | — | — | 1 | 5.57 |
| CHEMBL391778 | — | — | 1 | 5.54 |
| CHEMBL248115 | — | — | 1 | 5.46 |
| CHEMBL248321 | — | — | 1 | 5.46 |
| CHEMBL392273 | — | — | 1 | 5.44 |
| CHEMBL393848 | — | — | 1 | 5.41 |
| CHEMBL248108 | — | — | 1 | 5.37 |
| CHEMBL392664 | — | — | 1 | 5.30 |
| CHEMBL247104 | — | — | 1 | 5.27 |
| CHEMBL393264 | — | — | 1 | 5.21 |
| CHEMBL246687 | — | — | 1 | 5.19 |
| CHEMBL391779 | — | — | 1 | 5.14 |
| CHEMBL247309 | — | — | 1 | 5.12 |
| CHEMBL246284 | — | — | 1 | 5.06 |
| CHEMBL247513 | — | — | 1 | 5.02 |
| CHEMBL246898 | — | — | 1 | - |
| CHEMBL247914 | — | — | 1 | - |
| CHEMBL248322 | — | — | 1 | - |
| CHEMBL247512 | — | — | 1 | - |
| CHEMBL248114 | — | — | 1 | - |
| CHEMBL247916 | — | — | 1 | - |
| CHEMBL247915 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248116 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL391387 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL391778 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL248115 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL248321 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL392273 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL393848 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL248108 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL392664 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL247104 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL393264 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL246687 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL391779 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL247309 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL246284 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL247513 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL246898 | — | IC50 | - | — | - | |
| CHEMBL247914 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248322 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL247512 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL248114 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL247916 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL247915 | — | IC50 | > | 5000.0 | nM | - |