Assay Detail
Binding
CHEMBL923557
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Displacement of radioligand from human adenosine A3 receptor expressed in CHO cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.72 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175543 | — | — | 1 | 9.54 |
| CHEMBL2368455 | — | — | 1 | 9.42 |
| CHEMBL2368366 | — | — | 1 | 9.16 |
| CHEMBL2112163 | — | — | 1 | 9.11 |
| CHEMBL258421 | — | — | 1 | 9.09 |
| CHEMBL257405 | — | — | 1 | 9.01 |
| CHEMBL436649 | — | — | 1 | 8.93 |
| CHEMBL255907 | — | — | 1 | 8.89 |
| CHEMBL402574 | — | — | 1 | 8.89 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.85 |
| CHEMBL2112157 | — | — | 1 | 8.85 |
| CHEMBL27376 | — | — | 1 | 8.82 |
| CHEMBL2112161 | — | — | 1 | 8.82 |
| CHEMBL119709 | IB-MECA | — | 1 | 8.76 |
| CHEMBL283057 | — | — | 1 | 8.66 |
| CHEMBL257785 | — | — | 1 | 8.66 |
| CHEMBL257833 | — | — | 1 | 8.62 |
| CHEMBL257573 | — | — | 1 | 8.54 |
| CHEMBL2112162 | — | — | 1 | 8.54 |
| CHEMBL2368367 | — | — | 1 | 8.44 |
| CHEMBL256312 | — | — | 1 | 8.28 |
| CHEMBL256520 | — | — | 1 | 7.77 |
| CHEMBL402607 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175543 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL2368455 | — | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL2368366 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL2112163 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL258421 | — | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL257405 | — | Ki | = | 0.98 | nM | 9.01 |
| CHEMBL436649 | — | Ki | = | 1.17 | nM | 8.93 |
| CHEMBL255907 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL402574 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL2112157 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL27376 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL2112161 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL119709 | IB-MECA | Ki | = | 1.74 | nM | 8.76 |
| CHEMBL283057 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL257785 | — | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL257833 | — | Ki | = | 2.38 | nM | 8.62 |
| CHEMBL257573 | — | Ki | = | 2.88 | nM | 8.54 |
| CHEMBL2112162 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL2368367 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL256312 | — | Ki | = | 5.21 | nM | 8.28 |
| CHEMBL256520 | — | Ki | = | 17.1 | nM | 7.77 |
| CHEMBL402607 | — | Ki | = | 149.0 | nM | 6.83 |