Assay Detail
Binding
CHEMBL923765
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human GnRHR
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.31 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256109 | — | — | 2 | 9.52 |
| CHEMBL556355 | — | — | 1 | 9.44 |
| CHEMBL179691 | — | — | 1 | 9.25 |
| CHEMBL259906 | — | — | 1 | 9.21 |
| CHEMBL403234 | — | — | 2 | 9.15 |
| CHEMBL359894 | — | — | 1 | 8.49 |
| CHEMBL404180 | — | — | 1 | 8.43 |
| CHEMBL401632 | — | — | 1 | 8.38 |
| CHEMBL22653 | — | — | 1 | 8.35 |
| CHEMBL259907 | — | — | 1 | 8.35 |
| CHEMBL407719 | — | — | 1 | 8.31 |
| CHEMBL191817 | — | — | 1 | 8.28 |
| CHEMBL401807 | — | — | 1 | 8.13 |
| CHEMBL257599 | — | — | 1 | 7.70 |
| CHEMBL403081 | — | — | 1 | 7.48 |
| CHEMBL255242 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256109 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL556355 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL179691 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL259906 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL403234 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL359894 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL404180 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL401632 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL22653 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL259907 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL407719 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL191817 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL401807 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL257599 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL403081 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL256109 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL255242 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL403234 | — | Ki | = | 190.0 | nM | 6.72 |