Assay Detail
Functional
CHEMBL923908
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Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.60 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251024 | — | — | 1 | 9.50 |
| CHEMBL437204 | — | — | 1 | 9.30 |
| CHEMBL250832 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251024 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL437204 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL250832 | — | IC50 | = | 100.0 | nM | 7.00 |