Assay Detail
Binding
CHEMBL923909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I] labeled ligand from human P2Y12 receptor in human platelets
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.45 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251041 | — | — | 1 | 9.60 |
| CHEMBL249790 | — | — | 1 | 9.20 |
| CHEMBL266922 | — | — | 1 | 8.80 |
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 8.70 |
| CHEMBL398295 | — | — | 1 | 8.70 |
| CHEMBL398434 | — | — | 1 | 8.60 |
| CHEMBL274713 | — | — | 1 | 8.50 |
| CHEMBL250847 | — | — | 1 | 8.30 |
| CHEMBL250687 | — | — | 1 | 8.30 |
| CHEMBL249789 | — | — | 1 | 8.30 |
| CHEMBL249584 | — | — | 1 | 8.30 |
| CHEMBL535189 | — | — | 1 | 8.20 |
| CHEMBL250848 | — | — | 1 | 7.70 |
| CHEMBL401158 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251041 | — | Ki | = | 0.2512 | nM | 9.60 |
| CHEMBL249790 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL266922 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL398435 | TICAGRELOR | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL398295 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL398434 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL274713 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL250847 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL250687 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL249789 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL249584 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL535189 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL250848 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL401158 | — | Ki | = | 79.43 | nM | 7.10 |