Assay Detail
Binding
CHEMBL923927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SRC
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.89 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248393 | — | — | 1 | 7.57 |
| CHEMBL248392 | — | — | 1 | 7.35 |
| CHEMBL248391 | — | — | 1 | 7.31 |
| CHEMBL245800 | — | — | 1 | 7.07 |
| CHEMBL401251 | — | — | 1 | 6.96 |
| CHEMBL399438 | — | — | 1 | 6.85 |
| CHEMBL248044 | — | — | 1 | 6.82 |
| CHEMBL248045 | — | — | 1 | 6.77 |
| CHEMBL401644 | — | — | 1 | 6.68 |
| CHEMBL245799 | — | — | 1 | 6.55 |
| CHEMBL248220 | — | — | 1 | 6.48 |
| CHEMBL247024 | — | — | 1 | 6.24 |
| CHEMBL245798 | — | — | 1 | - |
| CHEMBL248222 | — | — | 1 | - |
| CHEMBL248221 | — | — | 1 | - |
| CHEMBL401054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248393 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL248392 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL248391 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL245800 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL401251 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL399438 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL248044 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL248045 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL401644 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL245799 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL248220 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL247024 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL245798 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL248222 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL248221 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL401054 | — | Ki | > | 10000.0 | nM | - |