Assay Detail
Functional
CHEMBL923942
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Cytotoxicity against HeLa cells by MTS assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 4.80 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248396 | — | — | 1 | 5.60 |
| CHEMBL245802 | — | — | 1 | 4.97 |
| CHEMBL400893 | — | — | 1 | 4.97 |
| CHEMBL400689 | — | — | 1 | 4.86 |
| CHEMBL247026 | — | — | 1 | 4.85 |
| CHEMBL247201 | — | — | 1 | 4.85 |
| CHEMBL445410 | — | — | 1 | 4.79 |
| CHEMBL399532 | — | — | 1 | 4.74 |
| CHEMBL395894 | — | — | 1 | 4.47 |
| CHEMBL247396 | — | — | 1 | 4.38 |
| CHEMBL247590 | — | — | 1 | 4.33 |
| CHEMBL245605 | — | — | 1 | - |
| CHEMBL397313 | — | — | 1 | - |
| CHEMBL248395 | — | — | 1 | - |
| CHEMBL398750 | — | — | 1 | - |
| CHEMBL440959 | — | — | 1 | - |
| CHEMBL399254 | — | — | 1 | - |
| CHEMBL247588 | — | — | 1 | - |
| CHEMBL396372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248396 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL245802 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL400893 | — | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL400689 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL247026 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL247201 | — | EC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL445410 | — | EC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL399532 | — | EC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL395894 | — | EC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL247396 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL247590 | — | EC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL245605 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL397313 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL248395 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL398750 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL440959 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL399254 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL247588 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL396372 | — | EC50 | > | 59300.0 | nM | - |